Factorio

GOG page
WASD and many other keys.

OSK works.

Requires LMB and RMB as well as the Mouse-Wheel.
No click to move, yet.

There are several Autohotkey profiles on the net that help navigating the game’s screen:

Controls can be inspected here:
https://github.com/mirkow/factoriomousecontrol
http://steamcommunity.com/app/427520/discussions/0/392184522719255183/

GUI can be scaled.

Has tutorials and tooltips.

Demo available on Steam.

CC-BY-SA